Simple bicarbonate buffer system for dissolution testing: Floating lid method and its application to colonic drug delivery system

In this study, we developed a simple and easy method to use bicarbonate buffer solutions for dissolution tests. A floating lid was newly introduced prevent the evaporation of CO2 from (the method). This used evaluate profiles 5-aminosalicylic acid (5-ASA) colonic delivery tablets with pH-sensitive film coating (5-ASA CDT) (Asacol® 400 mg tablet generic products B). sodium solution added test vessel, covered made foamed styrol, adjusted each pH an HCl (total 500 mL, 2–50 mM, 6.0 7.5). Without lid, value increased by more than one unit within 3.5 h. The suppressed increase in less 0.1 at h 0.7 22 According drug product information, all 5-ASA CDTs show similar disintegration times (approximately 0.5 h) release diluted McIlvaine (pH 7.5, 50 mM phosphate, 25 citrate). However, 10 mM), time prolonged 4.3 Asacol®, 8.0 A, 7.6 B. would be useful formulation development.